Description
Product Characteristics:
Aliases: ArPIKfyve antibody, FLJ10305 antibody, FLJ36622 antibody, FLJ46582 antibody, MGC149815 antibody, MGC149816 antibody, OTTHUMP00000174908 antibody, Protein VAC14 homolog antibody, Tax1 (human T cell leukemia virus type I) binding protein 1 antibody, Tax1 (human T cell leukemia virus type I) binding protein 2 antibody, Tax1 binding protein 2 antibody, Tax1-binding protein 2 antibody, TAX1BP2 antibody, TRX antibody, VAC 14 antibody, vac14 antibody, Vac14 homolog (S. cerevisiae) antibody, Vac14 homolog antibody, VAC14_HUMAN antibody
Target Information: The content of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. VAC14 is a component of a trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are the PtdIns(3,5)P2-synthesizing enzyme PIKFYVE (MIM 609414) and the PtdIns(3,5)P2 phosphatase FIG4 (MIM 609390). VAC14 functions as an activator of PIKFYVE (Sbrissa et al., 2007 [PubMed 17556371]).[supplied by OMIM, Feb 2010]